A human pan-disease blood atlas of the circulating proteome
- María Bueno Álvez
- Sofia Bergström
- Josefin Kenrick
- Emil Johansson
- Mikael Åberg
- Murat Akyildiz
- Ozlem Altay
- Hilda Sköld
- Konstantinos Antonopoulos
- Emmanouil Apostolakis
- Yasin Hasan Balcioglu
- Anna Bergström
- Göran Bergström
- Sophia Björkander
- Suzanne Egyhazi Brage
- Petter Brodin
- Lynn Butler
- Sara Cajander
- Hanna Danielsson
- Murat Dayangac
- Gizem Dinler-Doganay
- Levent Doğanay
- Gunilla Enblad
- Malin Enblad
- Linn Fagerberg
- Sara Falck-Jones
- Anna Färnert
- Mattias Forsberg
- Laura Gonzalez
- Anders Gummesson
- Karin Gunnarsson
- Iva Gunnarsson
- Ulf Gyllensten
- Göran Hesselager
- Andreas Hober
- Martin Höglund
- Marie Holmqvist
- Begum Horuluoglu
- Rebecka Hultgren
- Maria Jesus Iglesias
- Helena Janols
- Fredric Johansson
- Anette Johnsson
- Lars Klareskog
- David Kotol
- Inger Kull
- Marika Kvarnström
- Maximilian Julius Lautenbach
- Ulrika Liljedahl
- Henrik Lindman
2025-10-09
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and body mass index, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8262 individuals and up to 5416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research.