Nature Communications

Bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation

• Chhandosee Ganguly
• Swarmistha Devi Aribam
• Alberto Monteiro dos Santos
• Lindsie Martin
• Leonard M. Thomas
• Yihan Shao
• Rakhi Rajan

2026-01-28

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DOI https://doi.org/10.1038/s41467-026-68657-0