Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains
- Andrea I. Luppi
- Lynn Uhrig
- Jordy Tasserie
- Pedro A. M. Mediano
- Fernando E. Rosas
- S. Parker Singleton
- Daniel Gutierrez-Barragan
- Silvia Gini
- Pablo Castro
- Camilo M. Signorelli
- Daniel Golkowski
- Andreas Ranft
- Rüdiger Ilg
- Denis Jordan
- Kanako Muta
- Junichi Hata
- Hideyuki Okano
- Zhen-Qi Liu
- Yohan Yee
- Alain Destexhe
- Rodrigo Cofre
- David K. Menon
- Alessandro Gozzi
- Bechir Jarraya
- Emmanuel A. Stamatakis
2026-01-28
The mammalian brain orchestrates the processing and integration of information to guide behaviour. Here, to characterize mammalian information-processing architecture, we combine functional neuroimaging and anaesthesia in humans, macaques, marmosets and mice. We show that breakdown of information integration is a convergent effect of diverse anaesthetics across mammalian species. As the system disintegrates, brain dynamics become more difficult to control. Both effects are reversed upon re-awakening induced by thalamic deep-brain stimulation in the macaque. Regional breakdown of integrated information coincides with the species-specific spatial topography of PVALB/Pvalb gene expression. To provide mechanistic insight beyond correlation, we develop computational models for humans, macaques and mice that integrate species-specific connectivity and transcriptomic gradients, demonstrating their respective roles for controlling brain dynamics and information integration. We reveal evolutionarily conserved controllers of information integration in the mammalian brain.