Nature Communications

CRISPR-Cas9 trans-cleavage is hindered by a flanked R-loop, an elongated spacer, and an inactive HNH domain

• Roser Montagud-Martínez
• Raúl Ruiz
• Sara Baldanta
• Rubén Delicado-Mateo
• Guillermo Rodrigo

2026-01-24

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DOI https://doi.org/10.1038/s41467-026-68789-3