Nature

De novo design of GPCR exoframe modulators

• Shizhuo Cheng
• Jia Guo
• Yun-li Zhou
• Xumei Luo
• Gufang Zhang
• Ya-zhi Zhang
• Yixin Yang
• Jiannan Xie
• Ping Xu
• Dan-Dan Shen
• Shaokun Zang
• Huicui Yang
• Xuechu Zhen
• Min Zhang
• Yan Zhang

2026-02-16

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DOI https://doi.org/10.1038/s41586-025-09957-1