Family single-cell atlases reveal pig pregnancy and fetal growth restriction critical cell types
- Liping Cai
- Qing Zhang
- Tianxiong Yao
- Xiaoxiao Zou
- Lei Xie
- Siyu Yang
- Yanyuan Xiao
- Fei Huang
- Zhiwei Peng
- Jiawen Yang
- Jianzhen Huang
- Qiqi Jing
- Ziqi Ling
- Min Zheng
- Chuanmin Qiao
- Jinyuan Wu
- Jiaqi Chen
- Tao Jiang
- Qin Liu
- Min Liu
- Zhe Chen
- Jingquan Li
- Hui Jiang
- Haoyun Jiang
- Zuoquan Chen
- Yaya Liao
- Yizhong Huang
- Longyun Li
- Yunyan Zhou
- Zhou Zhang
- Chao Yin
- Yu Ye
- Hui Yang
- Biao Chen
- Zhong Wang
- Huanfa Gong
- Dong Chen
- Cong Huang
- Xinkai Tong
- Zhimin Zhou
- Hao Fu
- Yingchun Sun
- Xiao Sun
- Min Yan
- Lin Wu
- Shuqi Xiong
- Yaxiang Wang
- Xinke Xie
- Mengqing Zhou
- Xiaodong Liu
2026-03-26
Although massive cell atlases are already available, it is still a challenge to obtain an atlas of all tissues within a single body, especially in fetuses and pregnant mothers. We present a transcriptomic atlas of 2.56 million single cells covering 115 and 119 tissues from one fetal pig and its pregnant mother, respectively. We found that a cluster of heart capillary endothelial cells with enhanced fatty acid transit capability was enriched for pregnancy but restored after gestation. We also deciphered that l -leucine transport insufficiency in the trophoblast causes fetal growth restriction by reducing a muscle type II myofiber subcluster. Our “all-from-one” strategy enabled the identification of tissue cell type–specific transcription factors and provided insights into pregnancy heart adaptation and fetal growth restriction.