Genomic landscape of virus-associated cancers
- Yoonhee Nam
- Karen Gomez
- Jean-Baptiste Reynier
- Cole Khamnei
- Michael Aitken
- Vivian Zheng
- Tenzin Lhakhang
- Milena Casula
- Giuseppe Palmieri
- Antonio Cossu
- Arnold Levine
- Enrico Tiacci
- Raul Rabadan
2025-07-01
It has been estimated that 15%-20% of human cancers are attributable to infections, mostly by carcinogenic viruses. The incidence varies worldwide, with a majority affecting developing countries. Here, we conduct a comparative analysis of virus-positive and virus-negative tumors in nine cancers linked to five viruses. We observe a higher frequency of virus-positive tumors in males, with notable geographic differences in incidence. Our genomic analysis of 1971 tumors reveals a lower somatic burden, distinct mutation signatures, and driver gene mutations in virus-positive tumors. Compared to virus-negative cases, virus-positive cases have fewer mutations of TP53, CDKN2 A, and deletions of 9p21.3/ CDKN2 A- CDKN1A while exhibiting more mutations in RNA helicases DDX3X and EIF4A1 . Furthermore, an analysis of clinical trials of PD-(L)1 inhibitors suggests an association of virus-positivity with higher treatment response rate, particularly evident in gastric cancer and head and neck squamous cell carcinoma. Both cancer types also show evidence of increased CD8 + T cell infiltration and T cell receptor clonal selection in virus-positive tumors. These results illustrate the epidemiological, genetic, and therapeutic trends across virus-associated malignancies.