Science Advances

GPNMB, LRRK2, and lysosome exocytosis in Parkinson’s

2025-12-17

When two genes linked to increased Parkinson’s risk converge on a lysosome, LRRK2 mutation enhances lysosomal release of soluble GPNMB potentially contributing to synuclein pathology.

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DOI https://doi.org/10.1126/sciadv.aed8002