American Political Science Review
Heterogeneous Treatment Effects and Causal Mechanisms
2026-04-06
The credibility revolution advances the use of research designs that permit the identification and estimation of causal effects. However, understanding which mechanisms produce measured causal effects remains a challenge. The dominant current approach to the quantitative evaluation of mechanisms relies on the detection of heterogeneous treatment effects (HTEs) with respect to pretreatment covariates. This article develops a framework to understand when the existence of such HTEs can support inferences about the activation of a mechanism. We show first that this design cannot provide evidence of mechanism activation without additional, generally implicit, exclusion assumptions. Further, even when these assumptions are satisfied, the presence of HTEs supports the inference that the mechanism is active but the absence of HTEs is generally uninformative about mechanism activation. We provide novel guidance for interpretation and research design in light of these findings.