Science Advances

Implantable bioelectronic outlet

2026-07-08

Developing a reliable, long-term electrical interface for implanted bioelectronics is essential for chronic diagnostics, therapeutics, and device maintenance. Here, we introduce the implantable bioelectronic outlet (IBO), a soft, tissue-like electronic interface that enables on-demand, direct ohmic connection between implanted electronics and external devices. IBO is composed of a conducting polymer–coated low-density polymer matrix that is jacketed with a hydrophobic elastomer, allowing repetitive insertion of external electrical contacts without crack propagation. IBO was functional after 1 year of implantation with minimal tissue effects. We demonstrate that IBO enables high-fidelity, bidirectional transmission of signals and power, including low-voltage neurophysiological signals, high-speed digital signals, neurostimulation protocols, and efficient high-current power delivery, validated in small and large animal model studies. The IBO provides a robust and scalable platform for safe, direct, and durable electrical interfacing with implantable bioelectronics.

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DOI https://doi.org/10.1126/sciadv.aee9688