Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial
- Brittany N. Flores
- Seungyoon B. Yu
- Isaac V. Cohen
- Melania H. Fanok
- Wei Luan
- Romeo D. Maciuca
- Linus D. Sun
- Richard M. Tsai
- Maurits Vissers
- Lars Smits
- Tommy M. Bunte
- Anna Bakardjiev
- Srijana Balasundar
- Meredith E. K. Calvert
- Marcus Y. Chin
- Sarah K. Dobbins
- William E. Dowdle
- Meng Fang
- Jules A. A. C. Heuberger
- Connie L. Ha
- Fen Huang
- Takashi Miyamoto
- Maksim Osipov
- Lidia Madrid San Martin
- Katie Saund
- David Tatarakis
- Anthony Q. Vu
- Chenling Xiong
- Gene W. Yeo
- Geert Jan Groeneveld
- Leonard H. van den Berg
- Shyeilla Dhuria
- Anthony A. Estrada
- Danna Jennings
- Thomas Sandmann
- Carole Ho
- Kimberly Scearce-Levie
- Ernie Yulyaningsih
- Adam K. Walker
- Gilbert Di Paolo
- Lesley A. Kane
- Matthew D. Troyer
- Joseph W. Lewcock
2025-08-18