Science Advances

Rule-breaking in chemical synthesis

• Jordan A. M. Gonzalez
• Giulianna A. Miseo
• K. N. Houk
• Neil K. Garg

2026-06-17

Challenging century-old rules of structure, bonding, and reactivity enables the discovery of new synthetic chemistry involving amides and anti-Bredt olefins.

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DOI https://doi.org/10.1126/sciadv.aeg7124