Nature CommunicationsSingle-engineered-residue solvation perturbations regulate global protein architecture and functionYingya LiuJihang ZhaiShanshan CaoHuiying GuoHengwei ZhangBo SongJiajia GuoDong MenXiao HeDi Li2026-03-10Full textDOI https://doi.org/10.1038/s41467-026-70155-2