Substance P in the lateral hypothalamic area regulates binge‐like eating behaviors in mice
- Xin-Yue Lv
- Qian-Qian Yang
- Yue Wang
- Si Ran Wang
- Jiu-Ye Qiao
- Shuang Liu
- Hua-Li Yu
- Xiao-Xiao He
- Xiao-Juan Zhu
- Zi-Xuan He
2026-03-09
Binge eating disorder (BED) is the most common type of eating disorder; however, the neural circuit mechanisms underlying BED remain elusive. Here, we report that tachykinin-expressing neurons in the lateral hypothalamic area (LH Tac1 neurons) are inhibited during binge-like eating behaviors in mice. We identified LH Tac1 neurons as key mediators of binge-like eating behaviors and reported that the LH Tac1 → lateral periaqueductal gray (LPAG) circuit is critical to the regulation of binge-like eating behaviors. Moreover, Substance P (SP) released by LH Tac1 neurons modulates binge-like eating behaviors by influencing the input of glutamate to LPAG cells, which receive projections from LH Tac1 neurons. In summary, these findings point to the SP as a key node in BED circuits.