Nature Communications

Targeting a super-enhancer induced aldehyde dehydrogenase metabolic loop mitigates CDK4/6 inhibitor resistance in estrogen receptor-positive cancers

• Xiaochuan Chen
• Shini Liu
• Dandong Luo
• Dezheng Lin
• Jun Liu
• Huanmiao Zhan
• Shuqin Chen
• Peng Deng
• Zhaoliang Yu

2026-03-27

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DOI https://doi.org/10.1038/s41467-026-71144-1