The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity
- Tania Valencia
- Laura Y. Yen
- Cindy Berman
- Thomas Vincent
- Scott Davis
- Francesca Varrone
- Jianfeng Huang
- Jessica Mastroianni
- Morgan Carlson
- Tate Owen
- Amin Kamel
- Denis Drygin
- Garth A. Kinberger
- Shanti Pal Gangwar
- Maria V. Yelshanskaya
- John Ridley
- Robert Kirby
- Jesus Alvarez
- Ronak Lakhia
- Vishal Patel
- Alexander I. Sobolevsky
- Edmund C. Lee
2025-11-28